1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Basic information
- Product Name:
- 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
- Synonyms:
-
- Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-
- 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
- GBR 12783 DIHYDROCHLORIDE
- GBR127832HCl
- GBR 12921
- 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine
- GBR-12783
- 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine
- CAS:
- 67469-57-2
- MF:
- C28H32N2O
- MW:
- 412.57
- Product Categories:
-
- Dopamine receptor
- Mol File:
- 67469-57-2.mol
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Chemical Properties
- Melting point:
- >200°C (dec.)
- Boiling point:
- 551℃
- Density
- 1.085
- Flash point:
- 148℃
- storage temp.
- Desiccate at -20°C
- solubility
- Methanol (Slightly), Water (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis
Chemical Properties
White to off-white powder
Uses
GBR 12783 is a very potent and selective inhibitor of dopamine uptake.
Definition
ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane.
Biological Activity
A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
in vivo
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].
| Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; for 100 minutes |
| Result: | For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo. |
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDESupplier
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE(67469-57-2)Related Product Information
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- 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE