AG 1478 HYDROCHLORIDE Chemical Properties

Melting point:

247 °C(dec.)

Boiling point:

458.5±45.0 °C(Predicted)

Density 

1.337

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming

pka

5.54±0.30(Predicted)

form 

White to light yellow solid.

color 

Light orange to Yellow to Green

λmax

332nm(lit.)

Safety Information

RTECS 

VA0953000

HS Code 

29339900

AG 1478 HYDROCHLORIDE Usage And Synthesis

Uses

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Uses

AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

Biological Activity

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).

target

EGFR

AG 1478 HYDROCHLORIDE(153436-53-4)Related Product Information

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• N-(3-CHLORO-2-METHYLPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE
• (3-CHLORO-4-FLUORO-PHENYL)-(6,7-DIMETHOXY-QUINAZOLIN-4-YL)-AMINE
• N-(3,4-DICHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE