LOBAPLATIN
LOBAPLATIN Basic information
- Product Name:
- LOBAPLATIN
- Synonyms:
-
- d19466
- Lobaplatin (D-19466)
- Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME)
- Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI)
- Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-
- Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466
- cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe
- Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,κN′][(2S)-2-(hydroxy-κO)propanoato(2-)-κO]-, (SP-4-3)-
- CAS:
- 135558-11-1
- MF:
- C9H18N2O3Pt
- MW:
- 397.33
- EINECS:
- 604-604-1
- Mol File:
- 135558-11-1.mol
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LOBAPLATIN Chemical Properties
- Melting point:
- 220° (dec)
- storage temp.
- Store at -20°C
- solubility
- Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)
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LOBAPLATIN Usage And Synthesis
Biological Activity
Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.
LOBAPLATINSupplier
Hubei Kele Fine Chemical Co., Ltd Gold
- Tel
- 027-59101668 19945030958
- 2881924765@qq.com
Shanghai jerryxing Biomedical Technology Co., Ltd Gold
- Tel
- 17721492509; 17721492509
- 643638326@qq.com
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
Candia Thamtech Company Limited
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
Guangzhou Ciming Biological Technology Co., Ltd.
- Tel
- 020-38082199,29065168,38082986,29878298,29866629,4000192398