Basic information Safety Supplier Related

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

Basic information Safety Supplier Related

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Basic information

Product Name:
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
Synonyms:
  • 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
  • 4α-pma
  • 4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
  • (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
  • 4α-TPA
  • 4-alpha-Phorbol 12-Myristate 13-Acetate >99%
  • 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
  • 4-alpha-PMA, 4-alpha-TPA
CAS:
63597-44-4
MF:
C36H56O8
MW:
616.83
Product Categories:
  • metabolite
Mol File:
63597-44-4.mol
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties

storage temp. 
-20°C
solubility 
H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
form 
solid
color 
white
Sensitive 
Light Sensitive
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Safety Information

WGK Germany 
3
10-21

MSDS

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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Usage And Synthesis

Uses

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATESupplier

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