4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Basic information
- Product Name:
- 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
- Synonyms:
-
- 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
- 4α-pma
- 4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
- (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
- 4α-TPA
- 4-alpha-Phorbol 12-Myristate 13-Acetate >99%
- 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
- 4-alpha-PMA, 4-alpha-TPA
- CAS:
- 63597-44-4
- MF:
- C36H56O8
- MW:
- 616.83
- Product Categories:
-
- metabolite
- Mol File:
- 63597-44-4.mol
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
- form
- solid
- color
- white
- Sensitive
- Light Sensitive
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Safety Information
- WGK Germany
- 3
- F
- 10-21
MSDS
- Language:English Provider:SigmaAldrich
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Usage And Synthesis
Uses
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
Biochem/physiol Actions
Negative control for phorbol ester activation of protein kinase C.
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATESupplier
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Han-Xiang Chemical Co., Ltd.
- Tel
- 15971444841
- amber@biochempartner.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE(63597-44-4)Related Product Information
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- 2-ethylhexyl laurate
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- PHORBOL
- PHORBOL 12-MYRISTATE 13-ACETATE
- CYCLODODECENE
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- CYCLOHEPTENE
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- PHORBOL 13-ACETATE
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