ChemicalBook > CAS DataBase List > 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

Product Name
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
CAS No.
63597-44-4
Chemical Name
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
Synonyms
4α-TPA;4α-pma;alpha-TPA;4ALPHA-PMA;4ALPHA-TPA;4-alpha-PMA, 4-alpha-TPA;4α-Phorbol 12-myristate 13-acetate;4a-Phorbol 12-Myristate 13-Acetate;4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
CBNumber
CB4748443
Molecular Formula
C36H56O8
Formula Weight
616.83
MOL File
63597-44-4.mol
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Property

storage temp. 
-20°C
solubility 
H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
form 
solid
color 
white
Sensitive 
Light Sensitive
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Safety

WGK Germany 
3
F 
10-21
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P148
Product name
4α-Phorbol 12-myristate 13-acetate
Purity
solid, ≥95% (TLC)
Packaging
1mg
Price
$110.8
Updated
2024/03/01
Alfa Aesar
Product number
J61099
Product name
4alpha-Phorbol 12-myristate 13-acetate, 99%
Packaging
1mg
Price
$172
Updated
2023/06/20
Alfa Aesar
Product number
J61099
Product name
4alpha-Phorbol 12-myristate 13-acetate, 99%
Packaging
5mg
Price
$565
Updated
2021/12/16
Cayman Chemical
Product number
16806
Product name
4α-Phorbol 12-myristate 13-acetate
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
TRC
Product number
P353485
Product name
4α-Phorbol 12-myristate 13-acetate
Packaging
2.5mg
Price
$295
Updated
2021/12/16
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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties,Usage,Production

Uses

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Suppliers

China 11 Germany 1 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 8 Global 26
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
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80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
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58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3063
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
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58
Shanghai Yingxin laboratory equipment Co., Ltd
Tel
021-021-59178156 15300768757
Email
359382369@qq.com
Country
China
ProdList
10367
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58
Shanghai Guchen Biotechnology Co., LTD
Tel
021-34675735 19147740836
Email
1986399151@qq.com
Country
China
ProdList
9849
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58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58

63597-44-4, 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATERelated Search:

1,2-DIOCTANOYL-SN-GLYCEROL Prostratin, PKC activator (-)-INDOLACTAM V INGENOL 3,20-DIBENZOATE (+)-7-OCTYLINDOLACTAM V 2-ethylhexyl laurate CITRONELLYL VALERATE PHORBOL PHORBOL 12-MYRISTATE 13-ACETATE CYCLODODECENE CITRONELLYL BUTYRATE ISOAMYL LAURATE cis-1,2-Cyclohexanediol diacetate CYCLOHEPTENE 4ALPHA-PHORBOL 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE PHORBOL 13-ACETATE 1-CYCLOPROPYLETHANOL ACETATE

  • 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
  • 4α-pma
  • 4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
  • (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
  • 4α-TPA
  • 4-alpha-Phorbol 12-Myristate 13-Acetate >99%
  • 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
  • 4-alpha-PMA, 4-alpha-TPA
  • 4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
  • 4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
  • 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
  • 4ALPHA-PMA
  • 4ALPHA-TPA
  • Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
  • alpha-TPA
  • 4α-Phorbol 12-myristate 13-acetate
  • 4a-Phorbol 12-Myristate 13-Acetate
  • 63597-44-4
  • Serine/Threonine Kinase Activators
  • Protein Kinase C (PKC)
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • metabolite