ChemicalBook > CAS DataBase List > 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

Product Name
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
CAS No.
63597-44-4
Chemical Name
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
Synonyms
4α-TPA;4α-pma;alpha-TPA;4ALPHA-PMA;4ALPHA-TPA;4-alpha-PMA, 4-alpha-TPA;4α-Phorbol 12-myristate 13-acetate;4a-Phorbol 12-Myristate 13-Acetate;4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
CBNumber
CB4748443
Molecular Formula
C36H56O8
Formula Weight
616.83
MOL File
63597-44-4.mol
More
Less

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Property

storage temp. 
-20°C
solubility 
H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
form 
solid
color 
white
Water Solubility 
H2O: ~2μM
DMSO: soluble
ethanol: soluble
Sensitive 
Light Sensitive
More
Less

Safety

WGK Germany 
3
F 
10-21
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P148
Product name
4α-Phorbol 12-myristate 13-acetate
Purity
solid, ≥95% (TLC)
Packaging
1mg
Price
$285
Updated
2025/07/31
Cayman Chemical
Product number
16806
Product name
4α-Phorbol 12-myristate 13-acetate
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
TRC
Product number
P353485
Product name
4α-Phorbol 12-myristate 13-acetate
Packaging
2.5mg
Price
$295
Updated
2021/12/16
Usbiological
Product number
207019
Product name
4alpha-Phorbol 12-myristate 13-acetate
Packaging
1mg
Price
$299
Updated
2021/12/16
TRC
Product number
P353485
Product name
4α-Phorbol 12-myristate 13-acetate
Packaging
5mg
Price
$545
Updated
2021/12/16
More
Less

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties,Usage,Production

Uses

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Suppliers

China 26 Germany 1 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 9 Global 42
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Yingxin laboratory equipment Co., Ltd
Tel
021-021-59178156 15300768757
Email
359382369@qq.com
Country
China
ProdList
10674
Advantage
58
Shanghai Guchen Biotechnology Co., LTD
Tel
021-34675735 19147740836
Email
1986399151@qq.com
Country
China
ProdList
9844
Advantage
58
Tanmo Quality Inspection Technology Co., Ltd.
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
6043
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 13308200041
Email
2851167782@qq.com
Country
China
ProdList
11146
Advantage
58
Adipogen Life Sciences
Tel
41-6192660-40
Email
info@adipogen.com
Country
China
ProdList
5293
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Sperui Technology (Guangzhou) Co., Ltd.
Tel
18826050589
Country
CHINA
ProdList
186
Advantage
58
Shenzhen Campbell Biotechnology Co., Ltd.
Tel
18028747627
Country
CHINA
ProdList
191
Advantage
58
Aoki Biotechnology (Shenzhen) Co., Ltd.
Tel
18566777408
Country
CHINA
ProdList
156
Advantage
58
Beijing Zhongcheng Jinnian Technology Co., Ltd.
Tel
18510511586
Country
CHINA
ProdList
159
Advantage
58
Qingdao Everest Technology & Trade Co., Ltd.
Tel
13792478491
Country
CHINA
ProdList
161
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6523
Advantage
75

63597-44-4, 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATERelated Search:

1,2-DIOCTANOYL-SN-GLYCEROL Prostratin, PKC activator (-)-INDOLACTAM V INGENOL 3,20-DIBENZOATE (+)-7-OCTYLINDOLACTAM V 2-ethylhexyl laurate CITRONELLYL VALERATE PHORBOL PHORBOL 12-MYRISTATE 13-ACETATE CYCLODODECENE CITRONELLYL BUTYRATE ISOAMYL LAURATE cis-1,2-Cyclohexanediol diacetate CYCLOHEPTENE 4ALPHA-PHORBOL 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE PHORBOL 13-ACETATE 1-CYCLOPROPYLETHANOL ACETATE

  • 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
  • 4α-pma
  • 4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
  • (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
  • 4α-TPA
  • 4-alpha-Phorbol 12-Myristate 13-Acetate >99%
  • 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
  • 4-alpha-PMA, 4-alpha-TPA
  • 4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
  • 4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
  • 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
  • 4ALPHA-PMA
  • 4ALPHA-TPA
  • Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
  • alpha-TPA
  • 4α-Phorbol 12-myristate 13-acetate
  • 4a-Phorbol 12-Myristate 13-Acetate
  • 63597-44-4
  • Serine/Threonine Kinase Activators
  • Protein Kinase C (PKC)
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • metabolite