Flumethasone 21-pivalate Chemical Properties

Melting point:

>263°C (dec.)

Boiling point:

600.3±55.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)

form 

solid

pka

11.86±0.70(Predicted)

color 

White to Off-White

optical activity

[α]25/D 71.0 to 82.0°, c = 1 in dioxane

CAS DataBase Reference

2002-29-1(CAS DataBase Reference)

EPA Substance Registry System

Flumethasone-21-pivalate (2002-29-1)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

TU3832010

HS Code 

2937220000

Toxicity

mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982.

MSDS

• Language:English Provider:SigmaAldrich

Flumethasone 21-pivalate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

An anti-inflammatory anti-itching corticosteroid found in topical creams.

Uses

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).

Flumethasone 21-pivalate(2002-29-1)Related Product Information

• MAGNESIUM DIPROPYLACETATE HYDRATE
• Methyl acrylate
• Estradiol valerate
• Methyl trimethylacetate
• Methylparaben
• Bensulfuron methyl
• 2-Methylbutyl acetate
• Dexamethasone
• Glycidyl tertcarbonate
• Thiophanate-methyl
• Pivalic acid
• Flumethasone
• 4-tert-Butylcyclohexyl acetate
• Prednisolone
• Kresoxim-methyl
• Methyl
• Parathion-methyl
• Isoflupredone