4,5-DIMETHOXY-2-NITROBENZYL BROMIDE Chemical Properties

Melting point:

131-133 °C (lit.)

Boiling point:

372.3±37.0 °C(Predicted)

Density 

1.544

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Crystalline Powder or Needles

color 

Yellow to brown

Sensitive 

Lachrymatory

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

22-26-27-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich

4,5-DIMETHOXY-2-NITROBENZYL BROMIDE Usage And Synthesis

Uses

1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene is a useful research chemical.

Uses

4,5-Dimethoxy-2-nitrobenzyl bromide (DMNB bromide, 6-nitroveratryl bromide) is suitable reagent used in the synthesis of N-(4,5-dimethoxy-2-nitrobenzyl)vanillylamine which forms caged vanilloid. It may be used in the synthesis of the following:

• 4-(4′,5′-dimethoxy-2-nitrobenzyloxy)benzaldehyde, a DMNB-caged aldehyde
• N-[4-[(4,5-dimethoxy-2-nitrobenzyl)oxy]-3-methoxybenzyl]acetamide
• caged derivative of pyridostatin ([C]-PDS)
• photosensitive polyimide (PI-DMNB)
• caged β-ecdysone
• 4-tert-butyldimethylsilyloxy-1-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-2-(6-nitroveratrylthio)-1H-benzimidazole, an intermediate in synthesis of phosphoramidite bearing 4-hydroxy-2-mercaptobenzimidazole (SB^NV) nucleobase
• alkylation of dihydrofluorescein
• 4-(4′,5′-Dimethoxy-2′-nitrobenzyloxy)benzaldehyde

General Description

4,5-Dimethoxy-2-nitrobenzyl bromide (DMNBB, 1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene) is a 4,5-dimethoxy-2-nitrobenzyl derivative. 4,5-Dimethoxy-2-nitrobenzyl (DMNB) group of DMNBB is used as a photolabile protecting group in caging technology to develop pro-drugs. Synthesis of 1-(bromomethyl)-4,5-dimethoxy-2-nitrobenzene by using 6-nitroveratraldehyde as starting reagent has been reported.

4,5-DIMETHOXY-2-NITROBENZYL BROMIDE(53413-67-5)Related Product Information

• 3-(BROMOMETHYL)PHENOL
• 3-METHOXYBENZYL BROMIDE
• 2-(bromomethyl)-Benzenamine
• 4-Methoxybenzyl bromide
• 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE
• 4-AMINOCATECHOL HBR
• 4-Methoxy-2-nitrobenzyl bromide
• 2-Nitrobenzyl bromide
• 4-(BROMOMETHYL)PHENOL
• 3,4-DIMETHOXYBENZYL BROMIDE
• 2-(BROMOMETHYL)-4-METHOXY-1-NITROBENZENE