2-Nitrobenzyl bromide Chemical Properties

Melting point:

44-46 °C (lit.)

Boiling point:

265.51°C (rough estimate)

Density 

1.6841 (rough estimate)

refractive index 

1.6120 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

form 

Crystals or Crystalline Powder

color 

Yellow to light brown

Water Solubility 

insoluble

BRN 

638991

Stability:

Hygroscopic

CAS DataBase Reference

3958-60-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Nitrobenzyl bromide(3958-60-9)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

4.8-19-21

HazardClass 

8

PackingGroup 

II

HS Code 

29049085

MSDS

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2-Nitrobenzyl bromide Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

2-Nitrobenzyl bromide is used in the preparation of S-2-nitrobenzyl-cysteine by reaction with L-cysteine. It is also used for the introduction of the 2-nitrobenzyl protecting group in organic synthesis. It plays an important role in the production of expectorant agent. Further, it is employed for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. In addition to this, it is used in the preparation of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

Uses

2-Nitrobenzyl bromide was used for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. It can be used in the synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

Biochem/physiol Actions

2-Nitrobenzyl bromide reacts with L-cysteine to form S-2-nitrobenzyl-cysteine which was used for modification of ultra-low-gelling-temperature (ULGT) agarose.

2-Nitrobenzyl bromide(3958-60-9)Related Product Information

• 2-Nitrobenzyl alcohol
• Sodium 2-nitrophenoxide
• 2-Nitrodiphenylamine
• 2-Nitrophenylacetic acid
• 2-Nitrobenzaldehyde
• 2-Nitrobenzoic acid
• 2-NITRO-4-(TRIFLUOROMETHYL)BENZYL BROMIDE
• 2,4-DINITROBENZYL BROMIDE
• 2-FLUORO-6-NITROBENZYL BROMIDE,2-Fluoro-6-nitrobenzyl bromide 98%
• 4-Methoxy-2-nitrobenzyl bromide
• 2-Nitrobenzyl bromide
• 4,5-DIMETHOXY-2-NITROBENZYL BROMIDE,4,5-dimenoxy-2-nitrobenzyl bromide,4,5-Dimethoxy-2-nitrobenzyl bromide 95%
• 4-Bromomethyl-3-nitrobenzoic acid
• Methyl 2-bromomethyl-3-nitrobenzoate
• 4-BROMO-2-NITROBENZYL BROMIDE
• 3-FLUORO-4-NITROBENZYL BROMIDE
• 4-Nitrobenzyl bromide
• 4-Methoxy-3-nitrobenzyl bromide