Ozagrel hydrochloride Chemical Properties

Melting point:

214-217°

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

H₂O: soluble

form 

solid

color 

white to off-white

Merck 

14,6980

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.

CAS DataBase Reference

78712-43-3(CAS DataBase Reference)

Safety Information

RIDADR 

3077

WGK Germany 

2

RTECS 

UD3380000

HS Code 

29332900

Ozagrel hydrochloride Usage And Synthesis

Description

Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1?Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2?isomerase (IC50 > 1 mM).1?Inhibits platelet aggregation2?in vitro?and arachidonate-induced arterial contraction?in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4.

Uses

Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice.

Uses

Antithrombotic;Thromboxane synthase inhibitor

Definition

ChEBI: Ozagrel hydrochloride is an organic molecular entity.

References

1) Hiraku?et al. (1986),?Pharmacological studies on the TXA2?synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol.,?41?393 2) Naito?et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol.,?91?41 3) Edmonds and Leffer (1984),?Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci.,?35?1763 4) Tomishima?et al. (2013),?Ozagrel hydrochloride, a selective thromboxane A2?synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol.,?30?13

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