Bempedoic Acid-d4 Chemical Properties

form 

Solid

color 

White to off-white

Bempedoic Acid-d4 Usage And Synthesis

Uses

Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

References

[1] Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51. DOI:10.1194/jlr.M030528
[2] Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108. DOI:10.1194/jlr.M035212
[3] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110

Bempedoic Acid-d4(2408131-70-2)Related Product Information

• Bempedoic Acid Impurity 1-d4
• ETC-1002