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carboquone

Basic information Safety Supplier Related

carboquone Basic information

Product Name:
carboquone
Synonyms:
  • carboquone
  • Carbazilquinone
  • Esquinon
  • Carbazylquinone
  • 2,5-Cyclohexadiene-1,4-dione, 2-[2-[(aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl-
  • Esquinone
  • NSC 134679
  • p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6-methyl-, carbamate (ester) (8CI)
CAS:
24279-91-2
MF:
C15H19N3O5
MW:
321.33
Mol File:
24279-91-2.mol
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carboquone Chemical Properties

Melting point:
202° (dec)
Boiling point:
460.09°C (rough estimate)
Density 
1.1990 (rough estimate)
refractive index 
1.5600 (estimate)
pka
13.14±0.50(Predicted)
color 
Red to reddish-brown crystals
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Safety Information

Toxicity
LD50 in male mice, male rats (mg/kg): 6.09, 3.88 i.v.; 3.84, 3.16 i.p.; 30.8, 28.0 orally (Masuda, Suzuki)
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carboquone Usage And Synthesis

Originator

Esquinon,Sankyo,Japan,1974

Definition

ChEBI: Carboquone is an organic molecular entity.

Manufacturing Process

In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1- methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution was cooled. To the cooled solution was added 0.5 ml of aziridine and then the resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4 days. Thereafter, the crystalline substance which precipitated in situ was recovered by filtration and washed with ethanol to give 50 mg of the desired product as red crystals melting at 200°C (with decomposition).

Therapeutic Function

Antineoplastic

Safety Profile

A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx.

carboquone Preparation Products And Raw materials

Raw materials

carboquoneSupplier