carboquone
carboquone Basic information
- Product Name:
- carboquone
- Synonyms:
-
- carboquone
- Carbazilquinone
- Esquinon
- Carbazylquinone
- 2,5-Cyclohexadiene-1,4-dione, 2-[2-[(aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl-
- Esquinone
- NSC 134679
- p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6-methyl-, carbamate (ester) (8CI)
- CAS:
- 24279-91-2
- MF:
- C15H19N3O5
- MW:
- 321.33
- Mol File:
- 24279-91-2.mol
carboquone Chemical Properties
- Melting point:
- 202° (dec)
- Boiling point:
- 460.09°C (rough estimate)
- Density
- 1.1990 (rough estimate)
- refractive index
- 1.5600 (estimate)
- pka
- 13.14±0.50(Predicted)
- color
- Red to reddish-brown crystals
carboquone Usage And Synthesis
Originator
Esquinon,Sankyo,Japan,1974
Definition
ChEBI: Carboquone is an organic molecular entity.
Manufacturing Process
In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1- methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution was cooled. To the cooled solution was added 0.5 ml of aziridine and then the resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4 days. Thereafter, the crystalline substance which precipitated in situ was recovered by filtration and washed with ethanol to give 50 mg of the desired product as red crystals melting at 200°C (with decomposition).
Therapeutic Function
Antineoplastic
Safety Profile
A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx.