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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride

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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Basic information

Product Name:
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
Synonyms:
  • 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
  • Ethanone,1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-, hydrochloride (1:1)
  • 1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]ethanone hydrochloride
  • Isoprenaline impurity A
  • [2-(3,4-DIHYDROXYPHENYL)-2-OXOETHYL]-PROPAN-2-YLAZANIUM,CHLORIDE
  • U 12844A
  • 3',4'-DIHYDROXY-2-(ISOPROPYLAMINO)-ACETOPHENONE HYDROCHLORIDE
  • Norepinephrine Impurity 10
CAS:
16899-81-3
MF:
C11H15NO3.ClH
MW:
245.704
EINECS:
240-943-7
Mol File:
16899-81-3.mol
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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Chemical Properties

Melting point:
255-257℃
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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Usage And Synthesis

Uses

1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]-ethanone is an impurity of Isoprenaline (I874200, HCl salt) which is non-selective beta-adrenergic agonist. Isoprenaline is used in the treatment of bradycardia.

Preparation

Obtained by condensation of a-chloro-3,4- dihydroxy-acetophenone with isopropylamine in isopropanol at 65–70°. The amino ketone which separated was treated with concentrated hydrochloric acid (54%), (46%).

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