Basic information Uses Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Tyrosine derivatives >  N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester

N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester

Basic information Uses Safety Supplier Related

N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester Basic information

Product Name:
N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester
Synonyms:
  • N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester
  • N-ACETYL-3,5-DIIODE-L-TYROSINE ETHYL ESTER
  • (S)-Ethyl 2-acetaMido-3-(4-hydroxy-3,5-diiodophenyl)propanoate
  • ethyl 2-acetaMido-3-(4-hydroxy-3,5-diiodophenyl)propanoate
  • Ethyl N-acetyl-3,5-diiodo-L-tyrosinate
  • ethyl (2S)-2-acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoate
  • N-ACETYL DIIODOTYROSINE ETHYL ESTER
  • 5-diiodo-L-tyrosine ethyl ester
CAS:
21959-36-4
MF:
C13H15I2NO4
MW:
503.07
EINECS:
667-888-5
Product Categories:
  • 000-111
Mol File:
21959-36-4.mol
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N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester Chemical Properties

Boiling point:
491.8±45.0 °C(Predicted)
Density 
1.956±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
6.90±0.25(Predicted)
InChI
InChI=1S/C13H15I2NO4/c1-3-20-13(19)11(16-7(2)17)6-8-4-9(14)12(18)10(15)5-8/h4-5,11,18H,3,6H2,1-2H3,(H,16,17)/t11-/m0/s1
InChIKey
BPKHOPGWGZAARI-NSHDSACASA-N
SMILES
C(OCC)(=O)[C@H](CC1=CC(I)=C(O)C(I)=C1)NC(C)=O
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N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester Usage And Synthesis

Uses

(S)-Ethyl 2-acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoate is a useful research chemical compound.

Synthesis

60 g of N-acetyl-3,5-diiodo-L-tyrosine and 900 mL of absolute ethanol were added to a 2 L reaction flask and stirred at room temperature for 30 minutes, then 5.8 mL of thionyl chloride was added, and then the temperature was raised to 50 ℃. The reaction was stirred for 1 hour, and after the reaction was completed, the mixture was concentrated to dryness under reduced pressure. The crude product was dissolved in 500 mL of dichloromethane and washed twice with 300 mL of saturated sodium hydrogen carbonate solution. The crude product was filtered off with suction, then beaten in 100 mL dichloromethane, and concentrated to dryness. The organic phase was dried over anhydrous sodium sulfate and under reduced pressure. The mixture was washed with 10 mL of dichloromethane, and the obtained cake was dried under vacuum at 40 ℃ for 5 hours to obtain 56.1 g of a white powdery solid N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester. The yield was 88.3%, and the purity was 98.52%.

N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester Preparation Products And Raw materials

Raw materials

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