Eplivanserin
Eplivanserin Basic information
- Product Name:
- Eplivanserin
- Synonyms:
-
- VAIOZOCLKVMIMN-PRJWTAEASA-N
- EPLIVANSERIN
- (Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime
- 5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT2A,5-HT Receptor,Eplivanserin,SR46349,oral,dopamine,SR 46349,Inhibitor,inhibit,release
- 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-[2-(dimethylamino)ethyl]oxime, (1Z,2E)-
- Eplivanserin, 10 mM in DMSO
- CAS:
- 130579-75-8
- MF:
- C19H21FN2O2
- MW:
- 328.38
- Mol File:
- 130579-75-8.mol
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Eplivanserin Chemical Properties
- Boiling point:
- 453.4±55.0 °C(Predicted)
- Density
- 1.08
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.60±0.15(Predicted)
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Eplivanserin Usage And Synthesis
Uses
Eplivanserin is used in the treatment of dystonia.
in vivo
Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2].
IC 50
5-HT2A Receptor: 5.8 nM (IC50, in rat cortical membrane); 5-HT2A Receptor: 1.14 nM (Ki); 5-HT2C Receptor: 120 nM (IC50)
EplivanserinSupplier
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
ChemCell Biomedicine Co.,Ltd.
- Tel
- 020-13556033878 2965585218 13556033878
- chemcell@hotmail.com
Beijing HuaMeiHuLiBiological Chemical
- Tel
- 010-56205725
- waley188@sohu.com
Shanghai T&W Pharmaceutical Co., Ltd.
- Tel
- +86 21 61551611
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com