BOC-12-ADO-OH Chemical Properties

Melting point:

83.5-84.5 °C

Boiling point:

454.5±18.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

4.78±0.10(Predicted)

form 

powder

color 

colorless to white

BRN 

1980302

InChI

InChI=1S/C17H33NO4/c1-17(2,3)22-16(21)18-14-12-10-8-6-4-5-7-9-11-13-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)

InChIKey

NNPOZNVKUHYVEJ-UHFFFAOYSA-N

SMILES

C(O)(=O)CCCCCCCCCCCNC(OC(C)(C)C)=O

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

BOC-12-ADO-OH Usage And Synthesis

Description

Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

BOC-12-ADO-OH(18934-81-1)Related Product Information

• 6-Aminopenicillanic acid
• 12-AMINODODECANOIC ACID
• 12-(METHYLAMINO)DODECANOIC ACID
• BOC-12-ADO-OH