Ubamatamab
Ubamatamab Basic information
- Product Name:
- Ubamatamab
- Synonyms:
-
- Ubamatamab
- Research Grade Ubamatamab (DHJ31005)
- Research Grade Ubamatamab
- CAS:
- 2305629-50-7
- MW:
- 0
- Mol File:
- Mol File
More
Less
Ubamatamab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Ubamatamab Usage And Synthesis
Uses
Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity[1].
in vivo
Ubamatamab (REGN4018; 0.01-0.5 mg/kg; i.p; on days 6, 10, 13, 16, and 21) potently inhibits growth of intraperitoneal ovarian tumors[1].
Ubamatamab (REGN4018; 0.01-1 mg/kg; i.p; once a week; total of five doses) shows minimal and transient increases in serum cytokines and C-reactive protein, with no overt toxicity[1].
| Animal Model: | NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells[1] |
| Dosage: | 0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg |
| Administration: | i.p; on days 6, 10, 13, 16, and 21 |
| Result: | Significantly reduced tumor burden, and did not result in any changes in weight. |
| Animal Model: | Cynomolgus monkeys |
| Dosage: | 0.01, 0.1, or 1 mg/kg |
| Administration: | i.p; once a week; total of five doses |
| Result: | Showed minimal and transient increases in serum cytokines and C-reactive protein. |
References
[1] Alison Crawford, et al. A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci Transl Med. 2019 Jun 19;11(497):eaau7534. DOI:10.1126/scitranslmed.aau7534
UbamatamabSupplier
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
Biolab Reagents
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
Wuhan Jingkangen Biomedical Technology Co., Ltd
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
Changsha Fuzhen Biotechnology Co.，LTD
- Tel
- 0731-13823398 15111215862
- 313359644@qq.com