4-Hydroxymethyl Loratadine Chemical Properties

Melting point:

73-75°C

Boiling point:

594.2±50.0 °C(Predicted)

Density 

1.301±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

pka

13.56±0.10(Predicted)

color 

Pale Yellow

Stability:

Hygroscopic

InChI

InChI=1S/C23H25ClN2O3/c1-2-29-23(28)26-11-8-15(9-12-26)21-19-6-4-18(24)13-16(19)3-5-20-17(14-27)7-10-25-22(20)21/h4,6-7,10,13,27H,2-3,5,8-9,11-12,14H2,1H3

InChIKey

BCKYTUFUNAGTDV-UHFFFAOYSA-N

SMILES

N1(C(OCC)=O)CC/C(=C2\C3=NC=CC(CO)=C3CCC3=CC(Cl)=CC=C3\2)/CC1

4-Hydroxymethyl Loratadine Usage And Synthesis

Chemical Properties

Light-Yellow Solid

Uses

A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor.

Definition

ChEBI: 4-Hydroxymethyl Loratadine is a benzocycloheptapyridine.

4-Hydroxymethyl Loratadine(609806-40-8)Related Product Information

• Loratadine
• N-Methyl Desloratadine
• Loratadine
• Loratadine 2-Chloro IMpurity
• Desloratadine N-Hydroxypiperidine
• N-ForMyl Desloratadine
• 8-Dechloro-10-chloro Loratadine
• 8-Dechloro-7-chloro Loratadine
• 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
• Loratadine Impurity 15
• 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
• Loratadine Impurity 13
• Loratadine Impurity 13
• Loratadine Impurity 17
• 3-Hydroxy loratadine
• Loratadine Impurity 8
• (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
• 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity)