caudatin Chemical Properties

Boiling point:

617.9±55.0 °C(Predicted)

Density 

1.25

storage temp. 

4°C, protect from light

solubility 

DMF:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.24(Max Conc. mM)

form 

A solid

pka

11.93±0.70(Predicted)

color 

White to off-white

caudatin Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Gaodatin has inhibitory effect on the growth of various human-derived tumor cell lines such as human gastric cancer, colon cancer, and lung cancer.

Biological Activity

Caudatin, a C-21 steroid hormone derived from Cynanchum auriculatum (C. auriculatum), potently inhibits human glioma growth in vitro and in vivo by triggering cell cycle arrest and apoptosis.

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