2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro- Chemical Properties

Boiling point:

556.5±52.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

pka

8.43±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro- Usage And Synthesis

Uses

α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research[1].

References

[1] Sardar Ali, et al. Novel 5-(Arylideneamino)-1?H-Benzo[?d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies. ACS Omega. 2022 Nov 23;7(48):43468-43479. DOI:10.1021/acsomega.2c03854

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