ALPHA-GUANIDINOGLUTARIC ACID Chemical Properties

Boiling point:

414.7±55.0 °C(Predicted)

Density 

1.62±0.1 g/cm3(Predicted)

refractive index 

-20 ° (C=4, 2mol/L HCl)

storage temp. 

2-8°C

solubility 

PBS pH 7.2: >50 mg/ml

form 

White crystalline solid.

pka

3.28±0.10(Predicted)

color 

White to Almost white

Safety Information

HS Code 

2925.29.6000

ALPHA-GUANIDINOGLUTARIC ACID Usage And Synthesis

Description

GGA is a linear mixed-type inhibitor of nNOS having a K_i of 2.69 μM. It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.

Uses

α-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration[1].

Definition

ChEBI: N-Amidino-L-glutamate is a L-glutamic acid derivative.

References

[1] H Shiraga, et al. Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. J Neurochem. 1986 Dec;47(6):1832-6. DOI:10.1111/j.1471-4159.1986.tb13095.x

ALPHA-GUANIDINOGLUTARIC ACID(73477-53-9)Related Product Information

• Mifepristone
• ALPHA-GUANIDINOGLUTARIC ACID
• (S)-(-)-2-GUANIDINOGLUTARIC ACID S-METHYLISOTHIOUREA SALT
• α-guaiene,guaia-1(5),11-diene,[1S-(1a,4a,7a)]-1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethenyl)-azulene
• 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
• 2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro-
• 2-Propenoic acid, 3-(4-methylphenyl)-, 2-oxo-2H-1-benzopyran-4-yl ester, (2E)-
• α-Glucosidase-IN-29
• KRN7000
• α-galactosidase
• 5H-Indeno[1,2-b]pyridin-5-one, 6,7-dimethoxy-4-methyl-
• Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester
• 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-(phenylthio)-
• Benzenesulfonamide, N-[4-[5-(4-chlorophenyl)-1-oxo-2,4-pentadien-1-yl]phenyl]-4-(trifluoromethyl)-
• 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-bromo-3,5-dimethoxyphenyl)-6-(phenylthio)-