aspergillomarasmine A Chemical Properties

Boiling point:

637.6±55.0 °C(Predicted)

Density 

1.579±0.06 g/cm3(Predicted)

pka

2.12±0.23(Predicted)

aspergillomarasmine A Usage And Synthesis

Uses

Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators[1].

Definition

ChEBI: Aspergillomarasmine A is an aspartic acid derivative.

References

[1] Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2

aspergillomarasmine A(3484-65-9)Related Product Information

• N-Methyl-D-aspartic acid
• 3,3-BIS(N,N-DIPROPANOIC ACID)
• aspergillomarasmine A
• D-SS-(N-METHYLAMINO)ALANINE