H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH Basic information
- Product Name:
- H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
- Synonyms:
-
- [SER 25]-PROTEIN KINASE C FRAGMENT 19-31
- PROTEIN KINASE C [SER-25] (19-31)
- RFARKGSLRQKNV
- H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
- ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL
- [SER25]-PKC (19-31)
- [SER25]-PROTEIN KINASE C (19-31)
- L-Valine, L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysylglycyl-L-seryl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparaginyl-
- CAS:
- 136795-05-6
- MF:
- C67H118N26O17
- MW:
- 1559.82
- Product Categories:
-
- Neuroscience
- Enzyme Substrates
- Protein Kinase C (PKC)Peptides for Cell Biology
- Protein Kinase CSerine/Threonine Kinase Biology
- Protein Kinase Related Peptides
- Protein Kinase Substrates
- Serine/Threonine Kinase Substrates
- Substrates by Enzyme
- peptide
- Mol File:
- 136795-05-6.mol
H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH Chemical Properties
- storage temp.
- −20°C
- solubility
- insoluble in EtOH; ≥155.9 mg/mL in DMSO; ≥65.2 mg/mL in H2O
- form
- White to off-white powder.
MSDS
- Language:English Provider:SigmaAldrich
H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH Usage And Synthesis
Biological Activity
protein kinase c (19-31), (c67h118n26o17), a peptide with the sequence h-arg-phe-ala-arg-lys-gly-ser-leu-arg-gln-lys-asn-val-oh, mw= 1559.82. this peptide derived from the pseudo-substrate regulatory domain of pkca (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase c substrate peptide for testing the protein kinase c activity.protein kinase c also known as pkc, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. pkca has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and ca2+ handling in myocytes.figure1 formula of [ser25] protein kinase c (19-31)figure2 signaling pathway of protein kinase c1. mellor h, parker pj (1998). "the extended protein kinase c superfamily". biochem. j.. 332 ( pt 2): 281–922. nishizuka y (1995). "protein kinase c and lipid signaling for sustained cellular responses" (abstract). faseb j. 9 (7): 484–96.3. vicente micol. correlation between protein kinase c an activity and membrane phase behavior. departamento de bioquı´mica y biologı´a molecular
H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OHSupplier
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H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH(136795-05-6)Related Product Information
- ISOTOCIN
- [SER2]-NEUROMEDIN C
- H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN-OH
- (Ser8)-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)
- LYS(BIOTIN)-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
- H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
- H-ASN-VAL-OH
- PROTEIN KINASE C (19-31)