Nefazodone
Nefazodone Basic information
- Product Name:
- Nefazodone
- Synonyms:
-
- 3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy
- l)-5-ethyl-4-(2-phenoxyethyl)-
- BMY-13754
- SERZONE
- MJ-13754-1
- NEFAZODONE
- 2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE
- Nefazodone base
- CAS:
- 83366-66-9
- MF:
- C25H32ClN5O2
- MW:
- 470.01
- Product Categories:
-
- API
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 83366-66-9.mol
Nefazodone Chemical Properties
- Melting point:
- 180-182°C
- Boiling point:
- 599.6±60.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ~11 mg/mL at 60 °C
- form
- solid
- pka
- pKa 6.5 (Uncertain)
- color
- white
- CAS DataBase Reference
- 83366-66-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Nefazodone(83366-66-9)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- Hazardous Substances Data
- 83366-66-9(Hazardous Substances Data)
MSDS
- Language:English Provider:SigmaAldrich
Nefazodone Usage And Synthesis
Chemical Properties
Crystalline Solid
Originator
Dutonin,Bristol-Myers Squibb,USA
Uses
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
Definition
ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.
brand name
Serzone (Bristol-Myers Squibb).
Therapeutic Function
Antidepressant
Biological Functions
Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.
Nefazodone Preparation Products And Raw materials
Raw materials
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