N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemical Properties

Melting point:

333-335°C

Boiling point:

566.95° C (Predicted)

Density 

1.516±0.06 g/cm3(Predicted)

refractive index 

n20D 1.72 (Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly)

form 

Solid

pka

10.92±0.70(Predicted)

color 

Pale Yellow

Water Solubility 

Slightly soluble in water

InChI

InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)

InChIKey

LMXUWARKUIELGT-UHFFFAOYSA-N

SMILES

S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1

CAS DataBase Reference

302964-08-5(CAS DataBase Reference)

Safety Information

HS Code 

2933399990

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Usage And Synthesis

Description

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.

Chemical Properties

Pale Yellow Solid

Uses

Dasatinib intermediate. A protein tyrosine kinase inhibitor.

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide(302964-08-5)Related Product Information

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