N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Product Name: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS No.: 302964-08-5
Chemical Name: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Synonyms: Dasatinib Int N-1;CAY10697;2-((6-ChL;)amino)-N-(2-chL;dasatinib Dichloro;Dasatinib Impurity M;Dasatinib EP Impurity-D;Dasatinib Intermediate 1;Dasatinib Dichloro Impurity;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
CBNumber: CB51473109
Molecular Formula: C16H13Cl2N5OS
Formula Weight: 394.28
MOL File: 302964-08-5.mol

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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Property

Melting point:: 333-335°C
Boiling point:: 566.95° C (Predicted)
Density: 1.516±0.06 g/cm3(Predicted)
refractive index: n20D 1.72 (Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly)
form: Solid
pka: 10.92±0.70(Predicted)
color: Pale Yellow
Water Solubility: Slightly soluble in water
InChI: InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
InChIKey: LMXUWARKUIELGT-UHFFFAOYSA-N
SMILES: S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
CAS DataBase Reference: 302964-08-5(CAS DataBase Reference)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3675
Product name: 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Packaging: 1G
Price: $23
Updated: 2024/03/01

TCI Chemical

Product number: C3675
Product name: 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Packaging: 5G
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 17806
Product name: CAY10697
Purity: ≥98%
Packaging: 50mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 17806
Product name: CAY10697
Purity: ≥98%
Packaging: 100mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 17806
Product name: CAY10697
Purity: ≥98%
Packaging: 250mg
Price: $241
Updated: 2024/03/01

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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemical Properties,Usage,Production

Description

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.

Chemical Properties

Pale Yellow Solid

Uses

Dasatinib intermediate. A protein tyrosine kinase inhibitor.

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Suppliers

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Biocompounds Pharmaceutical Inc.

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View Lastest Price from N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-meth-ylphenyl)thiazole-5-carboxami-de 302964-08-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] 302964-08-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Hebei Guanlang Biotechnology Co,.LTD

Product: Dasatinib Intermediate 302964-08-5
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2023-06-19

302964-08-5, N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamideRelated Search:

Paraquat dichloride 2-(2-Aminothiazol-4-yl)glyoxylic acid N,N-Dimethylformamide Methylparaben Kresoxim-methyl Benzamide Methanol Acetonitrile Methyl acrylate Basic Violet 1 Chlorantraniliprole (E)-3-Ethoxyacryloyl chloride Formamide N-(2-cyanophenyl)picolinaMide Methyl Ammonium hexafluorophosphate Hexamethylphosphoramide Hexafluorobisphenol A

Dasatinib Int N-1

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]

dasatinib Dichloro

2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 95%

CAY10697

N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide

N-(2-CHLORO-6-METHYLPHENYL)-2-[(6-CHLORO-2-METHYL-4-PYRIMIDINYL)AMINO]-5-THIAZOLECARBOXAMIDE

2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Dasatinib Intermediate 1

2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl

2-[(6-chloro-2-MethylpyriMidin-4-yl)aMino]-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide

2-[(6-Chloro-2-methyl-4-pyrimidyl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide

Dasatinib Dichloro Impurity

)amino)-N-(2-chL

2-((6-ChL

N- (2-chloro-6-methylphenyl) -2-[(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazole-formamide

Dasatinib Impurity M

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidi...

Dasatinib EP Impurity-D

N - (2-chloro-6-methylphenyl) -2- [(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazolamide

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)ami]-5-thiazolecarboxamide

2-(6-Chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide

N-(2-Chloro-6-Methylphenyl)-2-[(6-chloro-2-Methyl-4-pyriMidinyl)aMino]-5-thiazolecarboxaMi

302964-08-5

2964-08-5

964-08-5

Dasatinib

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