N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- Product Name
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- CAS No.
- 302964-08-5
- Chemical Name
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- Synonyms
- Dasatinib Int N-1;CAY10697;2-((6-ChL;)amino)-N-(2-chL;dasatinib Dichloro;Dasatinib Impurity M;Dasatinib EP Impurity-D;Dasatinib Intermediate 1;Dasatinib Dichloro Impurity;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
- CBNumber
- CB51473109
- Molecular Formula
- C16H13Cl2N5OS
- Formula Weight
- 394.28
- MOL File
- 302964-08-5.mol
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Property
- Melting point:
- 333-335°C
- Boiling point:
- 566.95° C (Predicted)
- Density
- 1.516±0.06 g/cm3(Predicted)
- refractive index
- n20D 1.72 (Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly)
- form
- Solid
- pka
- 10.92±0.70(Predicted)
- color
- Pale Yellow
- Water Solubility
- Slightly soluble in water
- InChI
- InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
- InChIKey
- LMXUWARKUIELGT-UHFFFAOYSA-N
- SMILES
- S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
- CAS DataBase Reference
- 302964-08-5(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3675
- Product name
- 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- Packaging
- 1G
- Price
- $23
- Updated
- 2024/03/01
- Product number
- C3675
- Product name
- 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- Packaging
- 5G
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 17806
- Product name
- CAY10697
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 17806
- Product name
- CAY10697
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 17806
- Product name
- CAY10697
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $241
- Updated
- 2024/03/01
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemical Properties,Usage,Production
Description
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.
Chemical Properties
Pale Yellow Solid
Uses
Dasatinib intermediate. A protein tyrosine kinase inhibitor.
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide manufacturers
- Product
- 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-meth-ylphenyl)thiazole-5-carboxami-de 302964-08-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] 302964-08-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-03
- Product
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 302964-08-5
- Price
- US $1350.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2021-06-05