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(+)-SYLVATESMIN

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(+)-SYLVATESMIN Basic information

Product Name:
(+)-SYLVATESMIN
Synonyms:
  • Philligenin
  • Phillygenin, >98%
  • 4-[(3S,3aR,6R,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
  • (+)-Phillygenin
  • (1S)-1β-(3-Methoxy-4-hydroxyphenyl)-4α-(3,4-dimethoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan
  • (1S,3aβ,6aβ)-1β-(3-Methoxy-4-hydroxyphenyl)-4α-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
  • 4-[[(1S)-4α-(3,4-Dimethoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan]-1β-yl]-2-methoxyphenol
  • Phillygenin
CAS:
487-39-8
MF:
C21H24O6
MW:
372.41
Product Categories:
  • Miscellaneous Natural Products
Mol File:
487-39-8.mol
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(+)-SYLVATESMIN Chemical Properties

Melting point:
133℃
Boiling point:
534.9±50.0 °C(Predicted)
Density 
1.225
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form 
A crystalline solid
pka
9.84±0.35(Predicted)
color 
White to off-white
LogP
2.034 (est)
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(+)-SYLVATESMIN Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Forsythia.

Uses

(+)-Sylvatesmin is a useful research chemical compound found ias a lignan of forysthia intermedia.

Biological Activity

Phillygenin is an active component of Forsythia, which has many medicinal values, such as antioxidants, lowering blood lipids, and inhibiting low-density lipoprotein oxidation.

in vitro

1) Phillygenin shows a greater inhibition on mouse B16 melanoma cells potential than vincristine.
2) phillygenin had notable scavenging activity against DPPH, ABTS radicals, as well as potent reducing power in FRAP assay. < /p>

in vivo

The reference for rat is 5.6 mg/ml ( iv).

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