Basic information Safety Supplier Related

adoprazine

Basic information Safety Supplier Related

adoprazine Basic information

Product Name:
adoprazine
Synonyms:
  • adoprazine
  • 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine
  • Unii-7snb18Q89d
  • SLV 313
  • SLV313
  • Adoprazine (SLV313)
  • SLV 313;SLV313;SLV-313
  • Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
CAS:
222551-17-9
MF:
C24H24FN3O2
MW:
405.46
Mol File:
222551-17-9.mol
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adoprazine Chemical Properties

Boiling point:
565.0±50.0 °C(Predicted)
Density 
1.256
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
6.07±0.10(Predicted)
color 
Light yellow to yellow
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adoprazine Usage And Synthesis

Biological Activity

Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.

in vitro

Adoprazine (SLV313) has high affinity at human recombinant D 2 , D 3 , D 4 , 5-HT < sub> 2B , and 5-HT 1A receptors, with pK i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D 2 receptor antagonist and an efficacious serotonin 5-HT 1A receptor agonist, with E max value (% effect of 10 μM 5-HT) of 73 and pK B value of 8.5 .

in vivo

Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.

Animal Model: Male Wistar rats (275-350 g)
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: po; single
Result : Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

target

5-HT 1A Receptor

9 (pEC 50 )

D 2 < /sub> Receptor

9.3 (pA2)

D 3 Receptor

8.9 (pA2)

D 4 Receptor

8.0 (pKi)

5-HT 7 Receptor

7.2 (pKi)

5-HT 1A < /sub> Receptor

9.1 (pKi)

D 2 Receptor

8.4 (pKi)

D 3 Receptor

8.4 (pKi)

adoprazineSupplier

Chembest Research Laboratories Limited
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+86-21-20908456
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sales@BioChemBest.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
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info@chemexpress.com
AdooQ BioScience, LLC
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+1 (866) 930-6790
Email
info@adooq.com
LETOPHARM LIMITED
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+86-21-5821 5861
Email
sales@letopharm.com
SPIRO PHARMA
Tel
Email
eric_feng1954@126.com
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adoprazine(222551-17-9)Related Product Information