(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Basic information
- Product Name:
- (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
- Synonyms:
-
- (1r)-ethanon
- anatoxini
- (+/-)-ANATOXIN A
- (+/-)-ANATOXIN A FUMARATE
- (+/-)-ANATOXIN A FUMERATE
- (+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE
- (-)-Anatoxin
- (1β,6β)-5-Acetyl-9-azabicyclo[4.2.1]non-4-ene
- CAS:
- 64285-06-9
- MF:
- C10H15NO
- MW:
- 165.23
- Product Categories:
-
- Amines
- Intermediates & Fine Chemicals
- Acetylcholine receptor
- Nicotinic
- Pharmaceuticals
- Mol File:
- 64285-06-9.mol
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Chemical Properties
- alpha
- D25 +39.8°
- Boiling point:
- 293.09°C (rough estimate)
- Density
- 1.0203 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Desiccate at +4°C
- pka
- 9.4(at 25℃)
- form
- White solid.
- color
- Oil
- EPA Substance Registry System
- Ethanone, 1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl- (64285-06-9)
Safety Information
- Hazardous Substances Data
- 64285-06-9(Hazardous Substances Data)
- Toxicity
- LD50 i.p. in mice: 200 mg/kg (Carmichael)
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Usage And Synthesis
Acute toxicity
Intraperitoneal-mouse LDL0: 0.25 mg/kg
Occurrence
An oily alkaloid, anatoxin-a has been isolated from Anabaena jfos-aquae.
Uses
(+)-Anatoxin-a is a secondary, bicyclic amine alkaloid and cyanotoxin with acute neurotoxicity. The toxin is produced by at least four different genera of cyanobacteria and has been reported in North America, Europe, Africa, Asia, and New Zealand. Symptoms of anatoxin exposure are loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 4539, 1984 DOI: 10.1021/ja00328a040
Biological Activity
A potent nicotinic agonist (K i values are 1.25 and 1840 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Stimulates [ 3 H]-dopamine release from rat striatal synaptosomes (EC 50 = 136 nM).
Safety Profile
Poison by intraperitoneal route.An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATESupplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 4401179829988
- customerservice@ascentscientific.co.uk
- Tel
- 888-539-0666
- info@emmx.com
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com
- Tel
- 13348960310 13348960310
- 3003867561@qq.com