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5-Fluoro-1,3-isobenzofurandione

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5-Fluoro-1,3-isobenzofurandione Basic information

Product Name:
5-Fluoro-1,3-isobenzofurandione
Synonyms:
  • 5-fluoro-3-isobenzofurandione
  • 5-Fluoro-isobenzofuran-1,3-dione
  • 5-FLUORO-BENZO[C]FURAN-1,3-DIONE
  • 5-Fluoro-1,3-isobenzofurandione
  • 5-FLUORO-2-BENZOFURAN-1,3-DIONE
  • 4-FLUOROPHTHALIC ACID ANHYDRIDE
  • 4-FLUOROPHTHALIC ANHYDRIDE
  • 4-FLUOROBENZENE-1,2-DICARBOXYLIC ANHYDRIDE
CAS:
319-03-9
MF:
C8H3FO3
MW:
166.11
EINECS:
1312995-182-4
Product Categories:
  • Heterocycles
  • Carbonyl Compounds
  • Phthalic Acids, Esters and Derivatives
  • API intermediates
  • Carboxylic Acid Anhydrides
  • Organic Building Blocks
Mol File:
319-03-9.mol
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5-Fluoro-1,3-isobenzofurandione Chemical Properties

Melting point:
75-79 °C (lit.)
Boiling point:
148°C 20mm
Density 
1.55
Flash point:
>93°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in sodium hydroxide.
form 
powder to crystal
color 
White to Almost white
Sensitive 
Moisture Sensitive
BRN 
131281
InChIKey
XVMKZAAFVWXIII-UHFFFAOYSA-N
CAS DataBase Reference
319-03-9(CAS DataBase Reference)
EPA Substance Registry System
1,3-Isobenzofurandione, 5-fluoro- (319-03-9)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-42/43
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
2
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
IRRITANT, MOISTURE SENSITIVE
PackingGroup 
HS Code 
29173990

MSDS

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5-Fluoro-1,3-isobenzofurandione Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorophthalic anhydride is used in the preparation of 5-fluoro-2-pyridin-3-ylmethyl-isoindole-1,3-dione by reacting with C-pyridin-3-yl-methylamine.

Uses

4-Fluorophthalic anhydride can be used as a reactant to prepare:

  • 4-amino substituted phthalimides applicable as potential fluorescent probes and fluorescent bioactive compounds.
  • 4,4′-bis(4-fluorophthalimido)diphenyl ether monomer, which is used in the synthesis of cardo polymers via nucleophilic substitution polymerization reaction.
  • Asymmetric polyimides by a solution polycondensation reaction.

General Description

4-Fluorophthalic anhydride is a fluorinated building block commonly used in chemical synthesis for the preparation of polyimide, pesticides, herbicides, and fungicides. It can be synthesized by treating 4-chlorophthalic anhydride with potassium fluoride.

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