3-Nitrophthalic anhydride
3-Nitrophthalic anhydride Basic information
- Product Name:
- 3-Nitrophthalic anhydride
- Synonyms:
-
- 1,3-Isobenzofurandione, 4-nitro-
- 1,3-Isobenzofurandione,4-nitro-
- 3-Isobenzofurandione,4-nitro-1
- NSC 4134
- 3-Nitrophthalic anhydride, synthesis grade
- 4-Nitrobenzo[c]furan-1,3-dione, 4-Nitro-2-benzofuran-1,3-dione, 4-Nitroisobenzofuran-1,3-dione
- 3-Nitrophthalic anhydride,97%
- Phthalic anhydride, 3-nitro- (6CI,7CI,8CI)
- CAS:
- 641-70-3
- MF:
- C8H3NO5
- MW:
- 193.11
- EINECS:
- 211-373-6
- Product Categories:
-
- Anhydride Monomers
- Monomers
- Polymer Science
- Carbonyl Compounds
- Carboxylic Acid Anhydrides
- Organic Building Blocks
- Amines
- Aromatics
- Intermediates
- Building Blocks
- Carbonyl Compounds
- Carboxylic Acid Anhydrides
- Chemical Synthesis
- Organic Building Blocks
- Phthalic Acids, Esters and Derivatives
- Dyes intermediates
- Mol File:
- 641-70-3.mol
3-Nitrophthalic anhydride Chemical Properties
- Melting point:
- 163-165 °C (lit.)
- Boiling point:
- 329.3°C (rough estimate)
- Density
- 1.6392 (rough estimate)
- refractive index
- 1.4700 (estimate)
- storage temp.
- Store below +30°C.
- form
- Crystalline Powder
- color
- Beige to yellow
- Water Solubility
- MAY DECOMPOSE
- Sensitive
- Moisture Sensitive
- BRN
- 179963
- CAS DataBase Reference
- 641-70-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Nitrophthalic anhydride(641-70-3)
- EPA Substance Registry System
- 1,3-Isobenzofurandione, 4-nitro- (641-70-3)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- F
- 10-21
- TSCA
- Yes
- HS Code
- 29173980
MSDS
- Language:English Provider:3-Nitrophthalic anhydride
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
3-Nitrophthalic anhydride Usage And Synthesis
Chemical Properties
Beige to yellow crystalline powder
Uses
An intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472). Reactions with aminoquinazolinones yield phthalimidoquinazolinones.
Uses
4-Nitrophthalic Anhydride is an intermediate for the synthesis of the benzimidazole PARP inhibitor I, ABT-472. It reacts with aminoquinazolinones to yield phthalimidoquinazolinones.
Preparation
3-Nitrophthalic anhydride can be prepared by heating 3-nitrophthalic acid under various conditions and by the action of acetic anhydride, essentially as in the procedure described. The direct nitration of phthalic anhydride yields 3-nitrophthalic anhydride together with the isomeric 4-nitro compound.
Purification Methods
Crystallise it from *C6H6, *C6H6/pet ether, Me2CO, AcOH, or Ac2O (m 164-165o). Dry it at 100o. [Beilstein 17 III/IV 6149, 17/11 V 266.]
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3-Nitrophthalic anhydride(641-70-3)Related Product Information
- 3-Fluorophthalic anhydride
- 4-BROMO PHTHALIC ANHYDRUS
- Dimethyl phthalate
- cis-1,2,3,6-Tetrahydrophthalic anhydride
- Isatoic Anhydride
- 2-Nitrobenzoic acid
- 2-Nitrobenzaldehyde
- CIS-BUTENEDIOIC ANHYDRIDE
- PHTHALAMIDE
- O-Phthalimide
- Dibutyl phthalate
- Phthalonitrile
- Phthalic anhydride
- 3-Nitrophthalic acid
- 3-Nitrophthalhydrazide
- 3-Nitrophthalimide
- METHYL 2-NITROBENZOATE
- 3-(METHOXYMETHYL)ANILINE