3-Acetyl-DON 13C labeled Chemical Properties

Density 

1.425±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

Flash point:

2 °C

storage temp. 

−20°C

solubility 

Acetonitrile: Soluble

form 

Liquid

color 

Colorless to light yellow

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36

Safety Statements 

26-36/37-16

RIDADR 

UN 1648 3/PG 2

3-Acetyl-DON 13C labeled Usage And Synthesis

Uses

3-Acetyldeoxynivalenol-13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685)[1]. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative[2], is a blood-brain barrier (BBB) permeable mycotoxin[3].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. DOI:10.1177/1071100718790255
[2] Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95. DOI:10.1016/j.tiv.2013.06.003
[3] Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640. DOI:10.1371/journal.pone.0143640

3-Acetyl-DON 13C labeled(1217476-81-7)Related Product Information

• 3-ACETYLDEOXYNIVALENOL