BREVETOXIN PBTX-3 Chemical Properties

Density 

1.190±0.06 g/cm3(Predicted)

storage temp. 

-20C

solubility 

DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

Solid

pka

13.78±0.70(Predicted)

Safety Information

RIDADR 

3172

RTECS 

XW5885000

HazardClass 

6.1(a)

PackingGroup 

I

BREVETOXIN PBTX-3 Usage And Synthesis

General Description

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.

Biochem/physiol Actions

Primary TargetVoltage-dependent Na+ channel activator

Safety Profile

A poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.

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