Basic information Safety Supplier Related

BREVETOXIN PBTX-3

Basic information Safety Supplier Related

BREVETOXIN PBTX-3 Basic information

Product Name:
BREVETOXIN PBTX-3
Synonyms:
  • DIHYDROBREVETOXIN B
  • BREVETOXIN PBTX-3
  • BREVETOXIN PBTX-3, PTYCHODISCUS BREVIS
  • PUMILIOTOXIN
  • brevetoxint17
  • toxint-17
  • Brevetoxin B, 42-deoxo-42-hydroxy-
  • PBTX-3
CAS:
85079-48-7
MF:
C50H72O14
MW:
897.1
Mol File:
85079-48-7.mol
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BREVETOXIN PBTX-3 Chemical Properties

Density 
1.190±0.06 g/cm3(Predicted)
storage temp. 
-20C
solubility 
DMSO: soluble,Ethanol: soluble,Methanol: soluble
form 
Solid
pka
13.78±0.70(Predicted)
color 
White to off-white
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Safety Information

RIDADR 
3172
RTECS 
XW5885000
HazardClass 
6.1(a)
PackingGroup 
I
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BREVETOXIN PBTX-3 Usage And Synthesis

Uses

Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+?channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].

General Description

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.

Biochem/physiol Actions

Primary TargetVoltage-dependent Na+ channel activator

Safety Profile

A poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.

in vivo

Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18)?radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues[3]. .

Animal Model:Pregnant CD-1 mice[3]
Dosage:2.8 μg/kg
Administration:Intratracheal instillation; 2.8 μg/kg; gestational days 15–18
Result:Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure.?

References

[1] Jeglitsch G,et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284(2):516-25. PMID:9454792
[2] Zaias J,et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23(4):205-11. DOI:10.3109/08958378.2011.558936
[3] Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon.?2006 Dec 15;48(8):1018-26. Epub 2006 Aug 18. DOI:10.1016/j.toxicon.2006.08.008

BREVETOXIN PBTX-3Supplier

BOC Sciences
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Shenzhen Regent Biochemical Technology Co., Ltd.
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0755-85201366 18938635012
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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TargetMol Chemicals Inc.
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Chengdu Peter-like Biotechnology Co., Ltd.
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028-81700200 13308200041
Email
2851167782@qq.com
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