(R)-(+)-Ketorolac Chemical Properties

Melting point:

163-170°C

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder

color 

white to beige

optical activity

[α]/D +162 to +178°, c = 1 in methanol

(R)-(+)-Ketorolac Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

(R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Definition

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic keto olac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

Biochem/physiol Actions

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.

(R)-(+)-Ketorolac(66635-93-6)Related Product Information

• (S)-Ketorolac
• Ketorolac Impurity 48
• Ketorolac Impurity 43
• Ketorolac Impurity 31
• Ketorolac Impurity 24
• (5-chloro-1H-pyrrol-2-yl)-phenylmethanone
• Ethyl 2-(1H-pyrrol-2-yl)acetate
• Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)
• Ethyl-(5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate, racemic
• Ketorolac Impurity 54
• 4-HYDROXY KETOROLAC
• Ketorolac tromethamine
• Ketorolac Impurity 21
• KETOROLAC EP IMPURITY H
• Ketorolac EP IMpurity D
• 1-Descarboxy Ketorolac
• Ketorolac EP IMpurity G
• 2,2'-BIPYRROL