2-HYDROXY-5-NITROBENZYL BROMIDE Chemical Properties

Melting point:

144-149 °C(lit.)

Boiling point:

383.0±32.0 °C(Predicted)

Density 

1.795

refractive index 

1.6090 (estimate)

storage temp. 

2-8°C

solubility 

chloroform: soluble25mg/mL, clear, yellow

pka

6.16±0.30(Predicted)

form 

Crystalline Powder

color 

Beige to light brown

BRN 

1868798

CAS DataBase Reference

772-33-8(CAS DataBase Reference)

EPA Substance Registry System

Phenol, 2-(bromomethyl)-4-nitro- (772-33-8)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29089990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-HYDROXY-5-NITROBENZYL BROMIDE Usage And Synthesis

Chemical Properties

Beige to yellow crystalline powder

Uses

Reagent for sulfhydryl modification.1

Uses

2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..

Uses

2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045

General Description

2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.

Purification Methods

Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]

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