2-Isopropylimidazole Chemical Properties

Melting point:

129-131 °C (lit.)

Boiling point:

256-260 °C (lit.)

Density 

0.9894 (rough estimate)

refractive index 

1.5000 (estimate)

Flash point:

256-260°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol

pka

14.30±0.10(Predicted)

form 

Powder

color 

White to yellow to light brown

BRN 

107804

InChIKey

FUOZJYASZOSONT-UHFFFAOYSA-N

CAS DataBase Reference

36947-68-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Isopropylimidazole(36947-68-9)

EPA Substance Registry System

1H-Imidazole, 2-(1-methylethyl)- (36947-68-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

TSCA 

Yes

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Isopropylimidazole Usage And Synthesis

Chemical Properties

Yellow solid

Uses

2-Isopropylimidazole may be used in the preparation of following compounds:

• Tetragonal nickel(II) complexes, NiL₄X₂ (X = Cl^-, Br^-, I^-, SCN^-, SeCN^-, NO₃^-, ClO₄^-, PF₆^- or NiL₄XClO₄ (X = Cl^-, Br^-, I^-, SCN^-).
• 1-Dodecyl-2-isopropylimidazole.
• Bromidotetrakis(2-isopropyl-1H-imidazole-[κN³)copper(II) bromide.

Uses

2-Isopropylimidazole is a imidazole based compound, classified as a diazole and as an alkaloid. 2-Isopropylimidazole was investigated in animal studies as a new bone imaging agent.

General Description

2-Isopropylimidazole is an heterocyclic building block. The nitration of 2-isopropylimidazole has been reported.

Synthesis

Step 2: Synthesis of 2-isopropyl-1H-imidazole Nickel catalyst (1 g, 10 wt%) was added to a solution of 2-isopropyl-4,5-dihydro-1H-imidazole (10 g, 80.36 mmol) in ethanol (20 mL). The reaction mixture was heated to reflux for 48 hours and subsequently cooled to room temperature. Insoluble particles were removed by filtration and the filtrate was concentrated to dryness under reduced pressure to give 4 g of 2-isopropyl-1H-imidazole as a white solid in 41% yield.

References

[1] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 108

2-Isopropylimidazole(36947-68-9)Related Product Information

• Imidazole
• Diisopropylamine
• 1-Vinylimidazole
• N,N-Diisopropylethylamine
• Isopropyl alcohol
• ISOPROPYL LAURATE
• 2-Bromopropane
• Heptafluoroisopropyl iodide
• Cumene
• Isopropyl acetate
• N-Methyl-2-pyrrolidone
• 3-Methyl-2-butanone
• Isoproterenol
• 8-CYCLOPENTYL-1,3-DIMETHYLXANTHINE
• 1,3-Diisopropylimidazolium chloride
• 1,3-Diisopropylimidazolium tetrafluoroborate
• N-Isopropvlimdazole
• 2-ISOPROPYLBENZIMIDAZOLE