Basic information Safety Supplier Related

Aflibercept

Basic information Safety Supplier Related

Aflibercept Basic information

Product Name:
Aflibercept
Synonyms:
  • Aflibercept iso-osmotic ophthalmic
  • VEGF trap
  • VEGF Trap R1R2
  • Research Grade Aflibercept(DHD12629)
  • Aflibercept1
  • Research Grade Aflibercept
CAS:
862111-32-8
MF:
C4318H6788N1164O1304S32
MW:
0
Mol File:
Mol File
More
Less

Aflibercept Chemical Properties

form 
Liquid
color 
Colorless to light yellow
More
Less

Safety Information

Hazardous Substances Data
862111-32-8(Hazardous Substances Data)
More
Less

Aflibercept Usage And Synthesis

Description

In November 2011, the U.S. FDA approved the recombinant fusion protein aflibercept, administered as an intravitreal injection, for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD). Aflibercept differs from these agents in that it acts as a soluble decoy receptor that binds all VEGF isoforms more tightly than their native receptors, thereby diverting VEGF from its normal function. Aflibercept consists of a fusion of the second Ig domain of human VEGF receptor 1 and the third Ig domain of human VEGF receptor 2 fused to the constant region of (Fc) of human immunoglobulin G1. Aflibercept is a dimeric glycoprotein with a protein molecular weight of 97 kDa and glycoside molecular weight of 18 kDa. It is produced in recombinant Chinese hamster ovary (CHO) cells that overexpress the fusion protein. Aflibercept has subpicomolar affinity for VEGF-A (KD=0.66 pM for VEGF-A165 and 0.19 pM for VEGF-A121), the major driver of pathological angiogenesis and vascular leak in wet AMD.19 Ranibizumab and bevacizumab bind VEGF-A165 with lower affinity (KD=20.6 and 35.1 pM, respectively).

Originator

Regeneron Pharmaceuticals (United States)

brand name

Eylea

AfliberceptSupplier

Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
LUCKY PHARMA CO., LIMITED
Tel
0571-86403260 86403970
Email
lucky@lkbiology.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com