N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid Chemical Properties

Density 

1.43

storage temp. 

Store at -20°C

solubility 

H2O : 1.43 mg/mL (4.56 mM; Need ultrasonic)

form 

Powder

pka

3.41±0.10(Predicted)

color 

White to off-white

N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid Usage And Synthesis

Uses

Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

References

[1] Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956. DOI:10.1021/jm990004i
[2] Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. DOI:10.1158/1078-0432.CCR-07-4800
[3] Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55. DOI:10.1158/0008-5472.CAN-07-0297
[4] Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8. DOI:10.1158/0008-5472.CAN-05-0393

N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid(192203-60-4)Related Product Information

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