ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cell Cycle > CDK inhibitors > PHA-793887
PHA-793887
PHA-793887 Basic information
- Product Name:
- PHA-793887
- Synonyms:
-
- N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide
- CS-350
- 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide
- PHA-793887
- N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide
- 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide PHA-793887
- PHA-793887 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide
- PHA-793887;PHA793887
- CAS:
- 718630-59-2
- MF:
- C19H31N5O2
- MW:
- 361.48
- Product Categories:
-
- Inhibitors
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- Apis
- Mol File:
- 718630-59-2.mol
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PHA-793887 Chemical Properties
- Melting point:
- >147°C (dec.)
- Boiling point:
- 596.2±50.0 °C(Predicted)
- Density
- 1.176±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Methanol(Slightly)
- pka
- 13.74±0.40(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
- Stability:
- Hygroscopic
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PHA-793887 Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.
Definition
ChEBI: N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide is a piperidinecarboxamide.
target
CDK5/p25
PHA-793887Supplier
Zhengzhou HSH Science & Technology Co., Ltd. Gold
- Tel
- 0371-55932928 18937192232
- 1282296214@qq.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com