Methyl 4-bromo-2-(trifluoromethyl)benzoate Chemical Properties

Boiling point:

274.2±40.0 °C(Predicted)

Density 

1.598±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2916399090

Methyl 4-bromo-2-(trifluoromethyl)benzoate Usage And Synthesis

Application

Methyl 4-bromo-2-trifluoromethylbenzoate can be used as an organic intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical analysis processes.

Synthesis

Synthesis of methyl 4-bromo-2-(trifluoromethyl)benzoate (107): 4-bromo-2-(trifluoromethyl)benzoic acid (106; 1.6 g, 5.95 mmol) was dissolved in 20 mL of methanol. 2 mL of thionyl chloride was added slowly. After addition, the reaction mixture was stirred at 60 °C for 12 h and subsequently concentrated. To the residue was added 20 mL of ethyl acetate. The mixture was washed sequentially with saturated aqueous sodium bicarbonate and saturated brine, dried over anhydrous sodium sulfate and concentrated to give 1.6 g methyl 4-bromo-2-(trifluoromethyl)benzoate (107) as a yellow liquid. Yield 85%. LCMS: m/z 282.7 [M + H]+, tR = 1.79 min.

References

[1] Patent: US2012/28952, 2012, A1. Location in patent: Page/Page column 18-19
[2] Patent: WO2017/31213, 2017, A1. Location in patent: Paragraph 00419
[3] Patent: WO2013/175053, 2013, A1. Location in patent: Page/Page column 120-121

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