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IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine

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IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine Basic information

Product Name:
IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine
Synonyms:
  • IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine
  • Cinnarizine EP IMpurity E
  • Cinnarizine IMpurity E
  • 1,4-Dibenzhydrylpiperazine dihydrochloride
  • 1,4-bis-(Diphenylmethyl)piperazine
  • Cinnarizine Impurity 5(Cinnarizine EP Impurity E)
  • 1,4-Bis(benzhydryl)piperazine
  • Piperazine, 1,4-bis(diphenylmethyl)-
CAS:
216581-01-0
MF:
C30H30N2
MW:
418.57
Mol File:
216581-01-0.mol
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IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine Chemical Properties

Melting point:
>235°C (dec.)
Boiling point:
526.2±45.0 °C(Predicted)
Density 
1.122±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, Refrigerator, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated)
form 
Solid
pka
6.17±0.10(Predicted)
color 
White to Off-White
Stability:
Light Sensitive
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IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine Usage And Synthesis

Uses

1,4-Bis(benzhydryl)piperazine is a cinnarizine (C465300) impurity. Cinnarizine is an anti-vasoconstricting agent (1), as well as a calcium channel blocker (2,3) with antiallergic activity. Antihistaminic.

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