TAS-102
TAS-102 Basic information
- Product Name:
- TAS-102
- Synonyms:
-
- TAS-102
- Tipiracil hydrochloride-trifluridine mixt.
- TRIFLURIDINE-TIPIRACIL HYDROCHLORIDE MIXTURE
- TAS-102(Tipiracil hydrochloride-trifluridine mixt)
- Trifluridine-tipiracil hydrochloride mixt.
- TAS-102(TIPIRACIL, TRIFLURIDINE)
- TAS-102 (LONSURF)
- TAS102; TAS 102
- CAS:
- 733030-01-8
- MF:
- C19H23Cl2F3N6O7
- MW:
- 575.32
- Mol File:
- 733030-01-8.mol
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TAS-102 Chemical Properties
- Melting point:
- 170-172°C
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
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TAS-102 Usage And Synthesis
Uses
TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer.
Biological Activity
Anti cancer, Anti angiogenic
in vivo
Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].
| Animal Model: | Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2] |
| Dosage: | 150 mg/kg/day |
| Administration: | p.o.; twice a day for 14 days |
| Result: | Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models. |
TAS-102Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn