Vildagliptin iMpurity A-F Chemical Properties

Boiling point:

535.5±50.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

pka

11.63±0.20(Predicted)

InChI

InChI=1S/C7H10N2O3/c10-5-4-2-1-3-9(4)7(12)6(11)8-5/h4,6,11H,1-3H2,(H,8,10)/t4-,6?/m0/s1

InChIKey

GVQWXLTWWOSRCG-VKZKZBKNSA-N

SMILES

[C@@]12([H])CCCN1C(=O)C(O)NC2=O

Vildagliptin iMpurity A-F Usage And Synthesis

Uses

3-Hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione is an impurity of Vildagliptin (V305000), part of a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from their use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.

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