1-Adamantanol Chemical Properties

Melting point:

247 °C (subl.) (lit.)

Boiling point:

214.73°C (rough estimate)

Density 

0.8544 (rough estimate)

refractive index 

1.4880 (estimate)

Flash point:

240°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Crystalline Powder or Needles

pka

15.38±0.20(Predicted)

color 

White to off-white

Water Solubility 

Soluble in ethanol , methanol, and diethyl ether. Partly miscible in water.

Sublimation 

240 ºC

BRN 

1903952

InChIKey

VLLNJDMHDJRNFK-UHFFFAOYSA-N

CAS DataBase Reference

768-95-6(CAS DataBase Reference)

NIST Chemistry Reference

1-Adamantanol(768-95-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

RTECS 

AU4980000

Hazard Note 

Irritant

HS Code 

29061900

MSDS

• Language:English Provider:1-Hydroxyadamantane
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Adamantanol Usage And Synthesis

Outline

1-adamantanol is also known as 1-hydroxide adamantane, 1-tricyclo [3.3.1.1 (3.7)] decyl alcohol. At room temperature, it is white crystalline powder with the melting point higher than 240 ℃. It is soluble in organic solvents and insoluble in water with sublimation property. It can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to generate 1-adamantane acetic acid. 1-adamantyl acetate can further undergo bromination and hydrolyzed into 3-hydroxy-1-adamantyl acetate which can further react with vinylidene chloride to give 1, 3-adamantane di-acetic acid.
1-adamantanol can have Friedel-Crafts alkylation reaction acetanilide in the 98% sulfuric acid medium at room temperature for direct synthesis of 1, 3-bis (4-acetylamino-phenyl) adamantane which can undergo alkaline hydrolysis for synthesis of 1, 3 bis (4-aniline) adamantane. The synthetic route has many advantages including relative high reaction yield and easy purification, etc., therefore greatly facilitating the synthesis of 1, 3-diaryl adamantane derivatives.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

1-adamantanol can be used as the intermediate for synthesis of adamantanes derivatives. For example, it can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to give 1-adamantane acetic acid.

Description

1-Adamantanol is a cyclic molecule with a hydroxyl group. It is produced by the oxidation of 2-methyl-2-adamantanol. 1-Adamantanol has been shown to be an effective substrate for bioremediation in wastewater treatment plants and can be used as a precursor to produce trifluoroacetic acid.

Chemical Properties

white to off-white crystalline powder or needles

Uses

1-Adamantanol was used in the preparation of 1,3-adamantanediol. It is used in the manufacture of synthetic adamantane derivatives and adapalene.

Synthesis Reference(s)

Synthetic Communications, 19, p. 2061, 1989 DOI: 10.1080/00397918908052598
Tetrahedron Letters, 28, p. 1941, 1987 DOI: 10.1016/S0040-4039(00)96015-5

Purification Methods

If 2-adamantanol is a suspected impurity, then dissolve the substance (10g) in acetone (100mL) and add Jones's reagent [CrO3 (10.3g) in H2O (30mL)], then conc H2SO4 (8.7mL) is added dropwise (turns green in colour) until excess reagent is present (slight red colour). Stir overnight, decant the acetone solution from the Cr salts and adamantan-2-one, dry (Na2SO4) and evaporate to dryness. The residue (ca 7g) is chromatographed through Al2O3 (250g) and washed with 50% *benzene/pet ether (b 40-60o), then 100% Et2O (to remove any adamantan-2-one present) and the 1-adamantanol is then eluted with 5% MeOH in Et2O. The eluate is evaporated, and the residue is recrystallised from pet ether (b 30-60o) at -70o, m 287.2-288.5o. It also crystallises from MeOH and can be sublimed in vacuo. It has characteristic IR, max 3640, 1114, 1086, 982 and 930cm-1. [Schleyer & Nicholas J Am Chem Soc 83 182 1961.] [Beilstein 6 IV 391.] Alternatively, if free from the 2-isomer, dissolve it in tetrahydrofuran, dilute with H2O to precipitate the alcohol. Collect, dry and sublime it in a vacuum at 130o. [Stetter et al. Chem Ber 92 1629 1959.]

1-Adamantanol(768-95-6)Related Product Information

• Adamantane
• Amantadine
• Altrenogest
• 3-AMINO-1-ADAMANTANOL,1-AMINO-3-ADAMANTANOL,3-AMINO-1-ADAMANTANOL,1-AMINO-3-ADAMANTANOL,3-Amino-1-adamantanol Hydrate,3-Amino-1-adamantanol Hydrate
• 2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI)
• Dichloroacetyl chloride
• Vildagliptin Impurity 25
• Vildagliptin Impurity 6
• Vildagliptin IMpurity 2 (Mixture of DiastereoMers)
• N-acetic acid-1-aMino-3-adaMantanol
• Vildagliptin Impurity 19
• 1,3,5,7-tetrahydroxyadamantane
• L-Proline, 4-chloro-, trans-
• 2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)
• Vildagliptin Carboxylic Acid
• Vildagliptin iMpurity A-F
• Cyanuric acid
• cis-cyclo(Pro-Pro)