[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT Chemical Properties

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

Powder

Water Solubility 

Soluble to 1 mg/ml in water

Sequence

His-Ser-Asp-Ala-Val-{Cl-Phe}-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT Usage And Synthesis

Uses

[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].

Biochem/physiol Actions

VIP receptor antagonist

storage

Store at -20°C

References

[1] Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. DOI:10.1016/s0014-2999(96)00966-1
[2] Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. DOI:10.1152/ajpgi.1986.250.4.G553
[3] Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42. DOI:10.1152/ajpgi.1993.264.2.G237

[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT(102805-45-8)Related Product Information

• H-VAL-NH2 HCL
• (R)-HOMO-BETA-ALANINE HYDROCHLORIDE
• H-GLY-PHE-NH2 HCL
• L-Serinamide hydrochloride
• H-ILE-NH2 HCL
• H-THR-NH2 HCL
• Aviptadil
• H-TYR-GLY-NH2 HCL
• DL-NORLEUCINE AMIDE HYDROCHLORIDE
• H-TYR-NH2 HCL
• D-ASPARTIC ACID ALPHA-AMIDE HYDROCHLORIDE
• H-NLE-NH2 HCL
• 1-(N-ACETYLAMINO)-2-(4-CHLOROPHENYL)-ETHANE
• H-ALA-PHE-NH2 HCL
• AC-LYS-NH2 HCL
• H-ASN-NH2 HCL
• H-THR-NHME HCL
• H-LEU-ALA-NH2 HCL