POLYGODIAL Chemical Properties

Melting point:

57° (Barnes, Loder)

alpha 

D24 -131° (c = 0.96 in ethanol)

Boiling point:

330.7±35.0 °C(Predicted)

Density 

1.084±0.06 g/cm3(Predicted)

RTECS 

QJ2850000

storage temp. 

-20°C

solubility 

DMSO: soluble20mg/mL, clear

form 

powder

color 

white to beige

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

LogP

3.522 (est)

Safety Information

Risk Statements 

52/53

Safety Statements 

61

WGK Germany 

3

POLYGODIAL Usage And Synthesis

Description

Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2

Uses

Polygodial is a naturally occurring antifungal and antinociceptive.

Definition

ChEBI: Polygodial is an aldehyde.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

storage

Store at -20°C

References

1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590

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