BLU-554
BLU-554 Basic information
- Product Name:
- BLU-554
- Synonyms:
-
- N-(3-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}tetrahydro-2H-pyran-4-yl)acrylamide
- BLU-554
- N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
- BLU554, CPDB0942
- BLU-554, 98%, a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor
- CS-2345
- BLU-554;BLU 554
- Fisogatinib (BLU 554)
- CAS:
- 1707289-21-1
- MF:
- C24H24Cl2N4O4
- MW:
- 503.38
- Mol File:
- 1707289-21-1.mol
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BLU-554 Chemical Properties
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/mL; DMSO: 20 mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL; Ethanol: 0.2 mg/mL
- form
- A crystalline solid
- pka
- 13.77±0.40(Predicted)
- color
- White to light yellow
- InChIKey
- MGZKYOAQVGSSGC-DLBZAZTESA-N
- SMILES
- C(N[C@H]1CCOC[C@H]1NC1=NC=C2C(=N1)C=CC(C1=C(Cl)C(OC)=CC(OC)=C1Cl)=C2)(=O)C=C
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BLU-554 Usage And Synthesis
Uses
N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide is a fibroblast growth factor receptor 4 (FGFR4) inhibitor. BLU-554
in vivo
Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver[1].
| Animal Model: | Wild type male mice(FVB/NRj, 11-14?weeks of age)[1] |
| Dosage: | 10?mg/kg |
| Administration: | Oral gavage; for 4 hours (Pharmacokinetic study) |
| Result: | Tissue concentrations decreased in the order liver?>?kidney?>?small intestine?>?spleen?>?brain. |
IC 50
FGFR4: 5 nM (IC50)
BLU-554Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
- Tel
- 15000803246 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
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BLU-554(1707289-21-1)Related Product Information
- 3-Pyridinemethanamine, 6-(4-fluoro-1H-pyrazol-1-yl)-α-methyl-, (αR)-
- Cyclohexanecarboxamide, N-[(1R)-1-[6-(4-fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]-, cis-
- Pralsetinib
- cis-Pralsetinib hydrochloride (cis-BLU-667 hydrochloride)
- 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline