11-KETO FLUPROSTENOL Chemical Properties

Boiling point:

627.3±55.0 °C(Predicted)

Density 

1.331±0.06 g/cm3(Predicted)

solubility 

PBS (7.2): 29 mg/ml

pka

4.76±0.10(Predicted)

11-KETO FLUPROSTENOL Usage And Synthesis

Description

11-keto Fluprostenol is an analog of prostaglandin D₂ (PGD₂) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF_2α and acts primarily through the FP receptor.¹ Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP₂ receptor compared to PGD₂ and essentially no activity at the DP₁ receptor.²

Definition

ChEBI: 11-keto Fluprostenol is a prostanoid.

References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F_2α Nature 250(464),330-331(1974).
2. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D₂ is a potent and selective CRTH2/DP₂ receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003).

11-KETO FLUPROSTENOL(62145-07-7)Related Product Information

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• Fluprostenol