Xanthohumol I
Xanthohumol I Basic information
- Product Name:
- Xanthohumol I
- Synonyms:
-
- Xanthohumol I
- 2-Propen-1-one, 1-[2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-6-methoxy-7-benzofuranyl]-3-(4-hydroxyphenyl)-, (2E)-
- CAS:
- 688360-06-7
- MF:
- C21H22O6
- MW:
- 370.4
- Mol File:
- 688360-06-7.mol
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Xanthohumol I Chemical Properties
- Boiling point:
- 643.5±55.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- pka
- 7.47±0.40(Predicted)
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Xanthohumol I Usage And Synthesis
Uses
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC50s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC50s of 51.25 μM and 63.07 μM[1].
IC 50
AChE; BChE
References
[1] Orhan IE, et al. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine. 2018 Mar 15;42:25-33. DOI:10.1016/j.phymed.2018.03.009