4-Methylsulphonylacetophenone Chemical Properties

Melting point:

126-129 °C(lit.)

Boiling point:

305.56°C (rough estimate)

Density 

1.3339 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Crystalline Powder or Needles

color 

White to slightly yellow

CAS DataBase Reference

10297-73-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29144000

MSDS

• Language:English Provider:4-Methylsulphonylacetophenone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4-Methylsulphonylacetophenone Usage And Synthesis

Chemical Properties

white to slightly yellow cryst. powder or needles

Uses

4-(Methylsulfonyl)acetophenone is an impurity of Etoricoxib (E934100), which is a specific inhibitor of COX-2.

Uses

4′-(Methylsulfonyl)acetophenone may be used in the synthesis of:

• 3-(4-Methylsulfonylphenyl)-4-phenyl-2(5H)-furanone with potent apoptosis-inducing ability.
• Bromo-4-methylsulfonylacetophenone, an intermediate for preparing DL-threo-2-dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol.
• 1-N-Substituted-3,5-diphenyl-2-pyrazoline derivatives, which show promising anti-inflammatory activity.

4-Methylsulphonylacetophenone(10297-73-1)Related Product Information

• 4'-Methylacetophenone
• Dichloroacetonitrile
• Diphenyl ether
• 4-Nitroacetophenone
• 4'-Chloroacetophenone
• 4-Methylsulphonyl benzaldehyde
• 4'-Methoxyacetophenone
• 4'-Hydroxyacetophenone
• 3-Nitroacetophenone
• Phenyl salicylate
• 3-Methoxyacetophenone
• PHENYL VALERATE
• PIPERACETAZINE (250 MG)
• Etoricoxib Impurity 9
• 2-CHLORO-1,3-DIMETHYLAMINO TRIMETHINIUM HEXAFLUOROPHOSPHATE
• PHENYL RESIN
• Etoricoxib
• Etoricoxib Impurity 15